NFL Week 16 Betting Guide: Odds, Matchups and Spreads

Published by
Sports Illustrated

By Bill Enright With NFL action spread across four days in Week 16, these betting trends can identify the best bets for each game. Heading into the holiday weekend, the NFL action is spread out across four days. The Jaguars and Jets kick things off in Week 16 with their matchup Thursday night. Then, the bulk of the games are played Saturday on Christmas Eve, followed by three games on Christmas, and one Monday Night, which is a less-than-thrilling game between the Chargers and Colts. For those tracking 2022 betting trends, the underdogs still have an advantage with a 120-97-7 (55%) against the…

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